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Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
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Pulmonary aspergillosis presenting with recurrent haemoptysis
Blas Y Betancourt1, Adrian C Garofoli1, Jagbir S Sandhu2
1Department of Medicine, Metropolitan Hospital Center, New York and New York Medical College, Valhalla, New York, USA.
BMJ Case Reports
|July 9, 2015
Summary
Pulmonary aspergillosis can cause severe bleeding (hemoptysis). This case highlights surgical management of a fungal lung cavity causing persistent hemoptysis, with successful recovery after voriconazole treatment.
Area of Science:
- Pulmonology
- Infectious Diseases
- Surgical Pathology
Background:
- Pulmonary aspergillosis encompasses diverse clinical presentations.
- Hemoptysis is a serious complication, often necessitating surgical intervention.
- Fungal lung infections can mimic other pathologies, complicating diagnosis.
Observation:
- A 54-year-old male with prior tuberculosis and diabetes presented with persistent cough and haemoptysis.
- Chest CT identified a soft tissue mass, and initial conservative treatment failed to resolve recurrent, severe haemoptysis.
Findings:
- Despite bronchial arterial embolisation, persistent haemoptysis required right upper and middle lobectomy.
- Histopathology confirmed a fungal cavitary lesion, treated successfully with voriconazole.
Implications:
- This case underscores the importance of considering fungal infections in patients with risk factors and recurrent haemoptysis.
- Aggressive management, including surgery and targeted antifungal therapy, can achieve favorable outcomes in complex pulmonary aspergillosis cases.
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