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Chromogranin A levels and mortality in patients with severe sepsis
Chih-Hsin Hsu1, Luis F Reyes, Carlos J Orihuela
1a University of Texas Health Science Center San Antonio , San Antonio , TX, USA .
Insights
Chromogranin A (CgA) may predict mortality in severe sepsis. Higher CgA levels correlated with increased ICU and hospital mortality, particularly in patients without cardiovascular disease.
Area of Science:
- Biomarker research
- Critical care medicine
- Sepsis pathophysiology
Background:
- Chromogranin A (CgA) is an emerging biomarker.
- CgA shows potential for assessing mortality risk in severe sepsis.
Purpose of the Study:
- To evaluate the association between CgA levels and mortality risk in severe sepsis.
- To determine if CgA can predict outcomes in critically ill septic patients.
Main Methods:
- Serum CgA levels were measured in 50 hospitalized patients.
- Patients had severe sepsis with organ failure within 48 hours of admission.
Main Results:
- Elevated CgA levels trended with increased ICU and hospital mortality.
- Septic patients without cardiovascular disease who died in the ICU had significantly higher CgA levels (median 602.3 ng/ml) compared to survivors (median 205.5 ng/ml), p=0.01.
Conclusions:
- High CgA levels are predictive of ICU mortality.
- This association is specifically noted in severe sepsis patients without pre-existing cardiovascular disease.
Context:
Chromogranin A (CgA) is a novel biomarker with potential to assess mortality risk of patients with severe sepsis.
Objective:
Assess association of CgA levels and mortality risk of severely septic patients.
Methods:
Serum CgA levels were measured in 50 hospitalized, severely septic patients with organ failure <48 h.
Results:
Higher CgA levels trended toward higher ICU and hospital mortality. Patients without cardiovascular disease who died in the ICU had higher median (IQR) CgA levels 602.3 (343.3, 1134.3) ng/ml versus 205.5 (130.7, 325.9) ng/ml, p = 0.01.
Conclusions:
High CgA levels predict ICU mortality in severely septic patients without prior cardiovascular disease.