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Esophageal eosinophilia in pediatric patients with cerebral palsy

Ana Carolina Ramos de Nápolis1, Flavia Araujo Alves1, Erica Rodrigues Mariano de Almeida Rezende1

  • 1Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.

Einstein (Sao Paulo, Brazil)
|July 9, 2015
PubMed

Insights

Children with cerebral palsy (CP) have a higher rate of eosinophilic esophagitis (EoE) than the general pediatric population. Regular screening for EoE is recommended in CP patients due to potential overlap with other gastrointestinal issues.

Area of Science:

  • Pediatric Gastroenterology
  • Neurology
  • Allergy Immunology

Background:

  • Cerebral palsy (CP) is a common neurodevelopmental disorder.
  • Eosinophilic esophagitis (EoE) is an allergic inflammatory condition of the esophagus.
  • The co-occurrence of CP and EoE is not well-characterized.

Purpose of the Study:

  • To describe the clinical presentation, diagnostic findings, and outcomes of pediatric patients with both cerebral palsy and eosinophilic esophagitis.
  • To determine the frequency of eosinophilic esophagitis in a cohort of patients with cerebral palsy.

Main Methods:

  • Retrospective, descriptive study of medical records from a tertiary pediatric gastroenterology center.
  • Evaluation of 131 pediatric patients diagnosed with cerebral palsy between August 2005 and August 2013.
  • Analysis of clinical data, endoscopic findings, and esophageal eosinophil counts.

Main Results:

  • Seven out of 131 (5.3%) patients with CP were diagnosed with EoE.
  • The mean age at EoE diagnosis was 52.3 months, with a mean of 35 eosinophils per high-power field.
  • Common symptoms included recurrent vomiting and dysphagia; endoscopic findings included mucosal thickening and white plaques.

Conclusions:

  • The prevalence of EoE in pediatric patients with CP is higher than in the general pediatric population.
  • Investigating EoE in patients with CP is crucial as it may coexist with or be mistaken for other gastrointestinal disorders.
  • Routine screening for EoE should be considered in pediatric patients with cerebral palsy.
Abstract

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