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Time to Akt: Superior tumor-reactive T cells for adoptive immunotherapy

Anniek B van der Waart1, Willemijn Hobo1, Harry Dolstra1

  • 1Department of Laboratory Medicine - Laboratory of Hematology; Radboud university medical center ; Nijmegen, The Netherlands.

Oncoimmunology
|July 9, 2015
PubMed

T cells are crucial players in the protection against cancer, and can be used in adoptive cell therapy to prevent or treat relapse. However, their state of differentiation determines their effectiveness, with early memory cells being the most favorable. Here, we discuss restraining of differentiation to engineer the ultimate tumor-reactive T cell.

Keywords:
ACT: adoptive cell therapyAPC: antigen-presenting cellsAktAllo-SCT: allogeneic stem cell transplantationCAR: chimeric antigen receptorDCs: dendritic cellsIL-15IL-7MiHAs: minor histocompatibility antigensT-cell differentiationTCR: T-cell receptorTILs: tumor-infiltrating lymphocytesTcm: central memory TTeff: effector TTem: effector memory TTn: naive TTscm: stem cell memory TWntadoptive T cell therapydendritic cellstem cell transplantation

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