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Related Concept Videos

B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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T Cell Types and Functions01:24

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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T Cell Activation and Clonal Selection01:22

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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Cells of the Adaptive Immune Response01:23

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Defense Against Bacterial Pathogens01:31

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The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
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Related Experiment Video

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Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
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B cells drive Th2 responses by instructing human dendritic cell maturation.

Mohan S Maddur1, Jagadeesh Bayry2

  • 1Institut National de la Santé et de la Recherche Médicale ; Paris, France ; Centre de Recherche des Cordeliers; Equipe - Immunopathology and Therapeutic Immunointervention ; Paris, France ; Sorbonne Universités, UPMC Univ Paris , Paris, France ; Emory Vaccine Center; Yerkes National Primate Research Center; Emory University ; Atlanta, GA, USA.

Oncoimmunology
|July 9, 2015
PubMed
Summary

Human dendritic cells (DCs) mature when interacting with activated B cells. This interaction uniquely equips DCs to promote Th2 cell polarization, influencing immune responses.

Keywords:
B lymphocytesBAFF-R, B–cell-activating factor receptorBCR, B-cell receptorDAMPs, damage-associated molecular patternsDCs, dendritic cellsOX-40 ligandOX-40L, OX-40 ligandPAMPs, pathogen-derived molecular patterns (PAMPs)TACI, transmembrane activator and calcium-modulating cyclophilin ligand interactorTh2Tregs, regulatory T cellsantibody responseantitumordendritic cells

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Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
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Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
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Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Dendritic cells (DCs) are key regulators of immune cell function.
  • Immune cell interactions educate DCs, shaping adaptive immunity.

Purpose of the Study:

  • To investigate the impact of activated B cell interaction on dendritic cell maturation.
  • To determine if this interaction confers unique functional properties to DCs.

Main Methods:

  • Co-culture of human dendritic cells with activated B cells.
  • Analysis of dendritic cell maturation markers.
  • Assessment of T helper 2 (Th2) cell polarization

Main Results:

  • Human DCs exhibited significant maturation upon engagement with activated B cells.
  • Mature DCs demonstrated an enhanced capacity to induce Th2 cell polarization.

Conclusions:

  • Activated B cells induce a unique maturation phenotype in dendritic cells.
  • This B cell-mediated DC maturation promotes Th2-biased immune responses.