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Updated: Apr 7, 2026

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
Published on: September 25, 2019
T cell receptor-therapy in HBV-related hepatocellularcarcinoma
Antonio Bertoletti1, Maurizia Brunetto2, Mala K Maini3
1Program Emerging infectious Diseases; Duke-NUS Medical School ; Singapore, Singapore ; Singapore Institute for Clinical Sciences; ASTAR ; Singapore, Singapore ; School of Immunity and Infection; College of Medical and Dental Science; University of Birmingham ; Edgbaston, Birmingham, UK.
Abstract:
Adoptive transfer of lymphocytes expressing engineered T cell receptors (TCR) is a promising option for cancer treatment and could include hepatocellularcarcinoma (HCC), where therapeutic options are limited. We have recently investigated whether hepatitis B viral antigens can act as a HCC-specific antigen and thus be targeted by adoptively transferred HBV-specific TCR redirected T cells.
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