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Anti-Inflammatory Effect of Selected Dihydroxyflavones
S Umamaheswari1, K S Sridevi Sangeetha2
1Professor, Department of Pharmacology, Faculty of Pharmacy, Sri Ramachandra University , Porur, Chennai, Tamilnadu, India .
Journal of Clinical and Diagnostic Research : JCDR
|July 9, 2015
Summary
Selected dihydroxyflavones (DHF) demonstrated dose-dependent anti-inflammatory effects in rats. These flavone compounds show promise for managing inflammation by inhibiting paw edema.
Area of Science:
- Pharmacology
- Biochemistry
- Natural Products Chemistry
Background:
- Inflammation involves reactive oxygen species (ROS) from immune cells, potentially damaging tissues.
- Flavones, a class of polyphenols, possess antioxidant properties.
- Antioxidant activity of flavones may offer therapeutic benefits for inflammatory conditions.
Purpose of the Study:
- To evaluate the anti-inflammatory potential of specific dihydroxyflavones (DHF) in an animal model.
- To identify safe and effective DHF compounds for treating inflammation.
Main Methods:
- Investigated four dihydroxyflavone derivatives: 2',3'-dihydroxyflavone, 2',4'-dihydroxyflavones, 5,3'-dihydroxyflavone, and 7,3'-dihydroxyflavone.
- Assessed anti-inflammatory activity using the carrageenan-induced hind paw edema model in albino rats.
Main Results:
- All tested dihydroxyflavone derivatives exhibited anti-inflammatory activity.
- The inhibition of carrageenan-induced paw edema was dose-dependent and time-dependent.
Conclusions:
- The studied dihydroxyflavones possess significant anti-inflammatory properties.
- These findings suggest DHF as potential therapeutic agents for inflammatory diseases.
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