Related Experiment Video

Updated: Apr 7, 2026

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
09:12

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery

Published on: March 27, 2018

10.0K

[MODERN STRATEGY FOR THE TREATMENT OF PATIENTS WITH "HIBERNATING MYOCARDIUM"]

A V Patrikeev, V Ya Rudman, D A Maksimkin

    Klinicheskaia Meditsina
    |July 10, 2015
    PubMed

    Insights

    Endovascular treatment normalized coronary circulation in patients with post-infarction cardiosclerosis. Restoring blood flow revitalized hibernating myocardium, improving heart function and patient prognosis.

    Area of Science:

    • Cardiology
    • Vascular Surgery
    • Regenerative Medicine

    Context:

    • Post-infarction cardiosclerosis affects numerous patients, leading to chronic ischemia and adverse cardiac remodeling.
    • Hibernating myocardium, a viable but under-perfused heart muscle segment, represents a therapeutic target.
    • Endovascular treatment offers a minimally invasive approach to address coronary circulation issues.

    Purpose:

    • To evaluate the efficacy of endovascular treatment in patients with post-infarction cardiosclerosis.
    • To assess the impact of restored coronary circulation on hibernating myocardium function.
    • To determine the influence of this treatment on long-term disease prognosis.

    Summary:

    • The study analyzed endovascular treatment outcomes in 66 patients suffering from post-infarction cardiosclerosis.
    • Normalization of coronary blood flow in patients with viable hibernating myocardium was achieved.
    • This intervention successfully eliminated chronic ischemia, mitigated cardiac remodeling, and restored myocardial function.

    Impact:

    • Restored coronary circulation is crucial for the sustained function of hibernating myocardium.
    • The treatment demonstrated a beneficial influence on the overall prognosis for patients with post-infarction cardiosclerosis.
    • Timely restoration of blood flow is key to preserving and recovering cardiac function in affected individuals.

    More Related Videos

    Author Spotlight: Enhancing Coronary Artery Revascularization05:25

    Author Spotlight: Enhancing Coronary Artery Revascularization

    Published on: September 15, 2023

    1.4K
    Establishing a Swine Model of Post-myocardial Infarction Heart Failure for Stem Cell Treatment08:24

    Establishing a Swine Model of Post-myocardial Infarction Heart Failure for Stem Cell Treatment

    Published on: May 25, 2020

    7.6K

    Related Concept Videos

    Cardiomyopathy V: Interprofessional Care01:29

    Cardiomyopathy V: Interprofessional Care

    Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
    670
    Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

    Cardiomyopathy III: Hypertrophic Cardiomyopathy

    Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
    748
    Acute Coronary Syndrome IV: Interprofessional Care01:28

    Acute Coronary Syndrome IV: Interprofessional Care

    IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
    473
    Myocarditis III: Medical Management01:14

    Myocarditis III: Medical Management

    Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
    326
    Cardiomyopathy II: Dilated Cardiomyopathy01:30

    Cardiomyopathy II: Dilated Cardiomyopathy

    Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
    783
    Dysrhythmias VI: Management of Dysrhythmias01:25

    Dysrhythmias VI: Management of Dysrhythmias

    Dysrhythmia management involves a multifaceted approach, incorporating pharmacological treatments, medical procedures, surgical interventions, lifestyle modifications, and patient education.Pharmacological ManagementAntiarrhythmic Drugs:Class I (Sodium Channel Blockers): This class includes quinidine and procainamide, which reduce the speed of impulse conduction in the heart, stabilize the cardiac membrane, and control arrhythmias. Quinidine and procainamide are Class IA agents that prolong the...
    633