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Preproenkephalin mRNA expression in nucleus caudalis neurons is enhanced by trigeminal stimulation
T Nishimori1, M G Buzzi, M A Moskowitz
1Gene Neuroscience Unit, ARC/NIDA, Johns Hopkins School of Medicine, Baltimore, MD 21224.
Brain Research. Molecular Brain Research
|November 1, 1989
Abstract:
Electrical stimulation of trigeminal afferents increases expression of preproenkephalin mRNA in neurons of laminae I and II of the trigeminal nucleus caudalis in animals sacrificed 6 hours after the end of stimulation. More neurons express, and positive cells express at higher levels. These neurons thus express the mRNA corresponding to a major pain-modulating neurotransmitter gene with significant input-related plasticity.