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Related Experiment Video

Updated: Apr 7, 2026

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

Published on: September 1, 2022

Evolution of optogenetic microdevices.

Rajas P Kale¹, Abbas Z Kouzani², Ken Walder³

¹Deakin University School of Engineering , Faculty of Science, Engineering, and Built Environment, 75 Pigdons Road, Waurn Ponds, Victoria 3216, Australia ; Mayo Clinic Department of Psychiatry and Psychology , 200 First Street SW, Rochester, Minnesota 55905, United States.

|July 10, 2015

Summary

This summary is machine-generated.

Optogenetic techniques advance neuroscience by enabling precise control of neural pathways. This review details the evolution from tethered systems to wireless microdevices for improved preclinical brain research.

Keywords:

behavioral tests fiber coupling neurology optogenetics portable microdevices psychiatry tethering

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Last Updated: Apr 7, 2026

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

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Published on: January 15, 2015

Area of Science:

Neuroscience
Biomedical Engineering
Optogenetics

Background:

Optogenetic techniques offer precise modulation of neural pathways in preclinical research.
Traditional bench-top optogenetic systems are bulky, expensive, and tethered, limiting animal behavior.
Advancements are moving towards portable and implantable microdevices for naturalistic behavioral studies.

Purpose of the Study:

To review the evolution of optogenetic microdevices.
To analyze the benefits and drawbacks of tethered, portable, and implantable systems.
To discuss key components for optimizing optogenetic system efficiency.

Main Methods:

Literature review of optogenetic system development.
Comparative analysis of device attributes (power, size, weight).
Discussion of opsins, light sources, and fiber coupling.

Main Results:

Bench-top systems offer power-intensive capabilities but restrict movement.
Portable and implantable microdevices enable wireless operation and free animal movement.
Optimization of light delivery is crucial for system efficiency.

Conclusions:

Optogenetic microdevice technology has evolved significantly, offering greater flexibility for research.
Wireless, implantable systems are key for studying natural behaviors.
Careful consideration of device parameters is essential for developing advanced optogenetic tools.