A case of Graham-Little-Piccardi-Lasseur syndrome

Area of Science:

• Dermatology
• Immunology

Background:

• Graham-Little-Piccardi-Lasseur Syndrome (GLPLS) is a variant of lichen planopilaris.
• It presents with cicatricial scalp alopecia, non-cicatricial axillary and pubic alopecia, and keratosis pilaris-like lesions.

Observation:

• GLPLS is typically seen in middle-aged, postmenopausal women.
• The etiology remains largely unknown, but T-cell mediated immunity is implicated.
• A genetic predisposition may also play a role.

Findings:

• This report details a case of GLPLS in a 75-year-old woman.
• The patient exhibited the classic triad of symptoms: scalp alopecia, axillary/pubic alopecia, and follicular keratotic eruption.

Implications:

• This case reinforces the typical clinical presentation of GLPLS.
• Understanding the pathogenesis, potentially involving immune responses, is crucial for future management.
• Further research into the etiology and genetic factors of GLPLS is warranted.