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Enhanced analgesic activity by cyclodextrins - a systematic review and meta-analysis
Renan G Brito1,2, Adriano A S Araújo3, Jullyana S S Quintans1
1a 1 Federal University of Sergipe, Department of Physiology , São Cristóvão, Sergipe, Brazil +55 79 2105 6640 ; lucindojr@gmail.com ; lucindo@pq.cnpq.br.
Expert Opinion on Drug Delivery
|July 11, 2015
Summary
Cyclodextrins enhance the effectiveness of analgesics, improving pain relief. This drug delivery system shows significant efficacy in both clinical and preclinical studies, potentially reducing required therapeutic doses.
Area of Science:
- Pharmacology
- Drug Delivery Systems
- Medicinal Chemistry
Background:
- Analgesics are crucial for pain management but can have limited efficacy.
- Optimizing analgesic effectiveness necessitates advanced drug delivery systems.
Purpose of the Study:
- To systematically review and evaluate the analgesic activity of compounds complexed in cyclodextrins.
- To determine if cyclodextrin complexation enhances analgesic efficacy.
Main Methods:
- Systematic review of studies using keywords 'analgesics', 'cyclodextrins', and 'drug effects'.
- Searches conducted across SCOPUS, PUBMED, and EMBASE databases.
- Meta-analysis of preclinical data and comparison of clinical study results.
Main Results:
- 22 relevant papers were identified for the review.
- Clinical studies demonstrated improved efficacy of complexed drugs (25-83% difference vs. controls).
- Meta-analysis of preclinical studies showed significantly greater analgesic effect (p < 0.01) for complexed drugs.
Conclusions:
- Cyclodextrins significantly improve the efficacy of analgesic compounds.
- Cyclodextrin complexation is a valuable tool for enhancing analgesic effects.
- This approach may allow for reduced therapeutic doses, increasing drug potential.
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