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Oxygen deteriorates arterial function in type 1 diabetes
Daniel Gordin1,2,3, Luciano Bernardi1,4, Milla Rosengård-Bärlund1,2,3
1Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, POB 63, 00014, Helsinki, Finland.
Acta Diabetologica
|July 11, 2015
Summary
Short-term oxygen administration worsens arterial stiffness in type 1 diabetes (T1D) patients more than in controls. This finding is clinically relevant as arterial stiffness contributes to diabetic complications.
Area of Science:
- Cardiology
- Endocrinology
- Vascular Physiology
Background:
- Oxygen therapy can impair vascular function, particularly in individuals with pre-existing vascular issues.
- Type 1 diabetes (T1D) patients exhibit impaired vascular function even at rest.
- The impact of oxygen on arterial function in T1D is not well understood.
Purpose of the Study:
- To investigate the effects of short-term oxygen administration on arterial function in T1D patients.
- To compare these effects with those in non-diabetic control subjects.
Main Methods:
- Arterial stiffness was assessed using augmentation index (AIx) and pulse wave velocity equivalent (SI-DVP).
- Measurements were taken in 98 T1D patients and 49 controls during baseline and hyperoxia.
- Continuous, noninvasive finger pressure waveforms were utilized.
Main Results:
- Hyperoxia increased AIx and SI-DVP significantly in T1D patients, but not in controls.
- The rise in AIx, systolic, and diastolic blood pressure was greater in T1D patients compared to controls.
- P-values indicate statistical significance for observed changes.
Conclusions:
- Short-term oxygen administration negatively impacts arterial function in T1D patients.
- This deterioration is more pronounced in T1D patients than in healthy controls.
- Given the role of arterial stiffness in diabetic complications, these findings hold clinical significance.
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