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Related Concept Videos

Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

5.5K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
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Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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The Parathyroid Glands00:59

The Parathyroid Glands

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The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
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Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
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Related Experiment Video

Updated: Apr 7, 2026

Detection and Quantification of Calcitonin Gene-Related Peptide CGRP in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay
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Detection and Quantification of Calcitonin Gene-Related Peptide CGRP in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay

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Procalcitonin: present and future.

H H Liu1, J B Guo, Y Geng

  • 1Department of Emergency, Zhongshan Hospital, Xiamen University, Xiamen, China, lena_8888666@163.com.

Irish Journal of Medical Science
|July 11, 2015
PubMed
Summary
This summary is machine-generated.

Procalcitonin (PCT) aids in differentiating sepsis from other inflammatory conditions in critically ill patients. While valuable for guiding antibiotic therapy, further research is needed to confirm its safety and understand its biological role.

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Area of Science:

  • Biochemistry
  • Critical Care Medicine
  • Infectious Diseases

Background:

  • Critically ill patients face risks of sepsis and systemic inflammatory response syndrome (SIRS).
  • Procalcitonin (PCT) serves as a biomarker to distinguish infectious from non-infectious SIRS triggers.
  • PCT has shown potential in guiding antibiotic treatment for bacterial infections.

Purpose of the Study:

  • To review and discuss current evidence on Procalcitonin (PCT) utility in various clinical scenarios.
  • To highlight the need for further investigation into PCT's physiological role and therapeutic potential.
  • To assess the evidence supporting PCT-guided antibiotic management in intensive care units (ICUs).

Main Methods:

  • Literature review of studies on Procalcitonin (PCT) in clinical settings.
  • Analysis of existing data on PCT's efficacy in differentiating sepsis and guiding antibiotic therapy.
  • Evaluation of the need for randomized controlled trials (RCTs) and research into PCT kinetics and biological function.

Main Results:

  • Procalcitonin (PCT) is a useful biomarker for sepsis differentiation and antibiotic stewardship.
  • PCT elevation can occur in both infectious and non-infectious conditions, indicating it's not a perfect biomarker.
  • Evidence suggests PCT use may reduce antibiotic exposure, but its safety in daily ICU practice requires further validation through RCTs.

Conclusions:

  • Procalcitonin (PCT) is a valuable tool in managing critically ill patients, particularly for guiding antibiotic therapy.
  • Further research, including RCTs, is essential to validate PCT-guided strategies and elucidate its physiological role.
  • Understanding PCT's biological function is crucial for exploring immunoneutralization as a potential therapeutic approach for sepsis.