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Updated: Apr 7, 2026

Rapid Generation of Amyloid from Native Proteins In vitro
Published on: December 5, 2013
Fueling the Fire with Fibers: Bacterial Amyloids Promote Inflammatory Disorders
Caitlin N Spaulding1, Karen W Dodson1, Matthew R Chapman2
1Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
Abstract:
Bacterial infection is associated with increased morbidity in patients with systematic lupus erythematosus. In a recent Immunity paper, Gallo et al. (2015) report that extracellular DNA is bound tightly by bacterial amyloid fibrils during biofilm formation and that amyloid/DNA composites are immune stimulators when injected into mice, leading to autoimmunity.
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