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Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
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Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

Published on: May 19, 2020

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[Pathology of Opportunistic Infection of the Central Nervous System]

Masayuki Shintaku1

  • 1Department of Pathology, National Hospital Organization Kyoto Medical Center.

Brain and Nerve = Shinkei Kenkyu No Shinpo
|July 11, 2015
PubMed

Insights

This review details the histopathology of opportunistic central nervous system infections. It provides a foundation for understanding these infections and immune reconstitution inflammatory syndrome.

Area of Science:

  • Neuropathology
  • Infectious Diseases
  • Immunology

Context:

  • Opportunistic pathogens (bacteria, fungi, protozoa, viruses) frequently impact the central nervous system (CNS).
  • Host immune response is often diminished in opportunistic infections, leading to weak inflammatory and reparative tissue mechanisms.
  • Immune reconstitution inflammatory syndrome (IRIS) is a growing concern, particularly in acquired immunodeficiency syndrome (AIDS) patients, due to therapy-induced immune restoration.

Purpose:

  • To provide comprehensive classical histopathological descriptions of CNS opportunistic infections.
  • To establish a basis for advanced molecular pathological investigations.
  • To clarify the varied histopathological findings associated with these infections.

Summary:

  • This review details the histopathological features of opportunistic infections affecting the central nervous system.
  • It covers diverse microorganisms including bacteria, fungi, protozoa, and viruses.
  • The review also addresses the emerging challenge of immune reconstitution inflammatory syndrome (IRIS), especially in immunocompromised individuals.

Impact:

  • Facilitates a deeper understanding of CNS opportunistic infections and their histopathological manifestations.
  • Provides a foundational resource for future molecular pathology research in this field.
  • Aids in the diagnosis and management of complex infections in immunocompromised patients.

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