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Levels of Salivary Immunoglobulin A (SIgA) in HIV Infected Children
P Subramaniam1, K Kumar1, K L Girish Babu1
1From the Department of Pedodontics and Preventive Dentistry The Oxford Dental College, Hospital and Research Centre, Hosur Road, Bommanahalli.
Unlabelled:
Secretory IgA is the main type of immunoglobulin in saliva and is considered to be the main secretion factor of adaptive immunity in the mouth.
Objective:
To assess the effect of Anti Retroviral Therapy on SIgA levels in saliva of HIV infected children.
Study Design:
A cross-sectional sample of 50 HIV infected children aged 6-8 years were divided into 2 groups ; Group 1: children prior to onset of anti-retroviral therapy and Group 2: children undergoing anti-retroviral therapy. Stimulated whole saliva samples were collected from each child following I hour of breakfast. The samples were placed on ice packs and immediately transferred to a laboratory, processed and total SIgA quantification was estimated using ELISA. Data obtained was statistically analyzed.
Results:
Among HIV infected children, significantly low SIgA levels of 6.2 mg/dl was seen in children prior to ART.
Conclusion:
Salivary IgA levels were significantly low in HIV infected children, particularly in children prior to ART.
