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Published on: February 5, 2018
Analysis of the UHRF1 expression in serum and tissue for gastric cancer detection
Mengyuan Ge1, Zhen Gui, Xiaoming Wang
1a Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing Medical University Cancer Hospital & Jiangsu Cancer Hospital , Nanjing , China.
Objective:
To analyze the Ubiquitin-like with PHD and ring finger domains (UHRF) 1 expression in gastric cancer (GC).
Methods:
The concentrations of UHRF1 DNA in serum were compared between 187 GC patients and 56 healthy controls using real-time PCR. Immunohistochemical analysis using tissue microarrays was performed.
Results:
UHRF1 DNA levels were significantly higher in GC patients compared to healthy controls (p < 0.001) and have associations with age and lymph node metastasis (LNM). The UHRF1 expression was significantly higher in tumor tissue than matched normal tissues (p < 0.001).
Conclusions:
The UHRF1 expression in serum and tissue may represent a novel biomarker for GC diagnosis and prognosis.
