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[Infections caused by Candida krusei in newborn infants]
W Handrick1, C Schönborn, F B Spencker
1Klinik für Kindermedizin, Karl-Marx-Universität Leipzig.
Abstract:
Experiences are described about systemic infections with fungaemia due to Candida krusei in seven newborns treated in a department of neonatology because of several perinatal problems. The origin of this outbreak cold not be established. In six patients the infection was early detected and successfully treated with miconazole and/or ketoconazole, all six newborns recovered. Infections due to Candida krusei are extremely rare in humans. This report demonstrates the clinical picture of this infection in newborns.
Insights
Systemic Candida krusei fungaemia is rare in newborns. Early detection and treatment with azole antifungals like miconazole led to recovery in most cases, demonstrating effective management strategies for this challenging infection.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
- Mycology
Background:
- Candida krusei fungaemia is an exceptionally rare systemic infection in human neonates.
- Neonates with perinatal issues are susceptible to invasive fungal infections.
Purpose of the Study:
- To describe the clinical presentation and management of Candida krusei fungaemia in a cohort of seven newborns.
- To highlight the rarity and clinical significance of this fungal infection in a neonatal intensive care unit setting.
Main Methods:
- Retrospective case series analysis of seven neonates diagnosed with Candida krusei fungaemia.
- Review of clinical data, treatment protocols (miconazole, ketoconazole), and patient outcomes.
Main Results:
- Six out of seven neonates experienced early detection and successful treatment.
- All successfully treated neonates recovered from the systemic fungal infection.
- The origin of the outbreak could not be definitively identified.
Conclusions:
- Candida krusei fungaemia, though rare, can occur in neonates with underlying perinatal problems.
- Prompt diagnosis and treatment with azole antifungals are crucial for favorable outcomes.
- This case series underscores the importance of recognizing and managing rare fungal infections in vulnerable infant populations.