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Updated: Apr 7, 2026

A Unified Methodological Framework for Vestibular Schwannoma Research
Published on: June 20, 2017
Role of cyclins D1 and D3 in vestibular schwannoma
J Jabbour1, P Earls2, N Biggs3
1University of Notre Dame Australia School of Medicine,Sydney,New South Wales,Australia.
Background:
Vestibular schwannomas in younger patients have been observed to be larger in size and grow more quickly.
Objective:
This study aimed to evaluate the expression of three important cell cycle proteins, cyclin D1, cyclin D3 and Ki-67, in vestibular schwannoma patients separated into two age groups: ≤ 40 years or > 40 years.
Method:
Immunohistochemical detection of cyclin D1, cyclin D3 and Ki-67 was undertaken in 180 surgically resected vestibular schwannomas.
Results:
The proliferation index of vestibular schwannomas was statistically higher in the ≤ 40 years age group compared to that in the > 40 years age group (mean of 4.52 vs 3.27, respectively; p = 0.01). Overexpression of cyclin D1 and cyclin D3 was found in 68 per cent and 44 per cent of tumours, respectively.
Conclusion:
There was an increased Ki-67 proliferation index in the younger age group that appears to correlate with clinical behaviour. Vestibular schwannomas in both age groups show increased expression of cyclin D1 and cyclin D3.
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