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Primordial evolvability: Impasses and challenges.

Vera Vasas1, Chrisantha Fernando2, András Szilágyi3

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Summary
This summary is machine-generated.

The GARD model, a metabolism-first approach to the origin of life, is not evolvable due to its reliance on non-covalent bonds and lack of true autocatalysis. Reflexively autocatalytic networks offer a more promising path to life's origins.

Keywords:
AutocatalysisCatalytic reaction networksChemical evolutionCollectively autocatalytic setsEvolvabilityGARD modelMetabolism-first theoriesOrigin of life

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Area of Science:

  • Origin of Life Studies
  • Biochemistry
  • Systems Chemistry

Background:

  • Metabolism-first approaches propose self-replicating molecules as life's precursors.
  • The Graded Autocatalysis Replication Domain (GARD) model, based on amphiphilic molecules, is a prominent example.
  • Previous simulations suggested GARD lacks selectability, questioning its evolutionary potential.

Purpose of the Study:

  • To analyze the evolvability of the GARD model and similar metabolism-first scenarios.
  • To identify limitations in GARD's chemical assumptions for origin of life research.
  • To compare GARD's evolvability with alternative models like reflexively autocatalytic networks.

Main Methods:

  • Evolutionary simulations of the GARD model.
  • Analysis of chemical kinetics and network dynamics.
  • Comparison of GARD with reflexively autocatalytic networks.

Main Results:

  • GARD model lacks true evolvability; selection has minimal impact.
  • Non-covalent bond chemistry and random catalytic interactions in GARD hinder autocatalysis.
  • Lognormal distribution of catalytic factors leads to kinetic instability.
  • Reflexively autocatalytic networks, utilizing covalent bond formation/breakage, demonstrate superior evolvability.

Conclusions:

  • GARD model is unlikely to be a viable precursor to life due to inherent limitations.
  • Open-ended evolvability requires chemical reactions forming/breaking covalent bonds, not just incorporation.
  • Reflexively autocatalytic networks represent a more plausible pathway for the origin of life.