Related Experiment Video
Updated: Apr 7, 2026
Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
Published on: August 28, 2018
Generalized arterial calcification of infancy--Findings at post-mortem computed tomography and autopsy
Ferdia Bolster1, Zabiullah Ali1, Pamela Southall1
1Office of the Chief Medical Examiner, State of Maryland, 900 West Baltimore Street, Baltimore, MD 21223, USA.
Insights
Generalized arterial calcification in infancy is a rare genetic disorder causing artery calcification and stenosis. Post-mortem imaging and autopsy reveal key pathological findings in affected infants.
Area of Science:
- Cardiovascular Pathology
- Pediatric Genetics
- Radiology
Background:
- Generalized arterial calcification in infancy (GACI) is a rare, severe genetic disorder.
- Characterized by abnormal calcification and myointimal proliferation in large and medium arteries.
- Leads to arterial stenosis, often resulting in fatal cardiac complications.
Observation:
- This report details findings from post-mortem computed tomography (CT).
- Histological examination of affected arteries was performed.
- Autopsy findings provided comprehensive pathological data.
Findings:
- Post-mortem CT revealed widespread arterial calcification and stenosis.
- Histology confirmed marked myointimal proliferation and vascular remodeling.
- Autopsy correlated imaging and histological findings with clinical outcomes.
Implications:
- Understanding GACI's pathology is crucial for diagnosis and management.
- Post-mortem analysis aids in characterizing rare genetic vascular diseases.
- Further research into GACI pathogenesis may reveal therapeutic targets.
Abstract:
Generalized arterial calcification in infancy is a rare genetic disorder characterized by abnormal calcification of large and medium sized arteries and marked myointimal proliferation resulting in arterial stenosis. The condition is often fatal secondary to complications of cardiac ischemia, hypertension and cardiac failure. In this report we describe the findings at post mortem computed tomography, histology and autopsy.
More Related Videos
08:02Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals
Published on: November 15, 2024
08:43Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
Published on: May 31, 2016
Related Concept Videos
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
01:20Imaging Studies for Cardiovascular System III: X-Ray
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
01:10Computed Tomography
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
01:28Imaging Studies for Cardiovascular System V: CT
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies