Related Experiment Video
Updated: Apr 7, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
AgSCF3-Mediated Trifluoromethylthiolation/Radical Cascade Cyclization of 1,6-Enynes
Yi-Feng Qiu1, Xin-Yu Zhu1, Ying-Xiu Li1
1†State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.
Abstract:
A AgSCF3-mediated radical cascade cyclization/trifluoromethylthiolation of 1,6-enynes triggered by a C-C triple bond is developed. This protocol also provides another opportunity to construct a valuable trifluoromethylthio-substituted polycyclic fluorene system through the formations of one C-SCF3 bond and two C-C bonds in a single step.
More Related Videos
10:10Application of Elemental Lanthanides in the Selective C-F Activation of Trifluoromethylated Benzofulvenes Providing Access to Various Difluoroalkenes
Published on: July 28, 2018
08:12A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
Published on: August 16, 2018
Related Concept Videos
Thermal and Photochemical Electrocyclic Reactions: Overview
Electrophilic 1,2- and 1,4-Addition of X2 to 1,3-Butadiene
Benzene to 1,4-Cyclohexadiene: Birch Reduction Mechanism
Preparation and Reactions of Sulfides
Mass Spectrometry: Cycloalkene Fragmentation
Electrophilic Addition to Alkynes: Halogenation
Halogenation is another class of electrophilic addition reactions where a halogen molecule gets added across a π bond. In alkynes, the presence of two π bonds allows for the addition of two equivalents of halogens (bromine or chlorine). The addition of the first halogen molecule forms a trans-dihaloalkene as the major product and the cis isomer as the minor product. Subsequent addition of the second equivalent yields the tetrahalide.