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Analgesia and Pain Management

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...

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Updated: Apr 7, 2026

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform

Published on: November 30, 2016

MicroRNA expression profiles differentiate chronic pain condition subtypes.

Brittney P Ciszek¹, Asma A Khan¹, Hong Dang²

¹Center for Pain Research and Innovation, University of North Carolina, Chapel Hill, NC.

Translational Research : the Journal of Laboratory and Clinical Medicine

|July 14, 2015

Summary

This summary is machine-generated.

MicroRNAs (miRNAs) show distinct expression patterns in chronic pelvic pain patients, particularly those with co-occurring irritable bowel syndrome. These miRNA differences may help differentiate pain subtypes for tailored treatments.

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Development of Recombinant Proteins to Treat Chronic Pain

Development of Recombinant Proteins to Treat Chronic Pain

Published on: April 11, 2018

Area of Science:

Biomedical Science
Molecular Biology
Pain Research

Background:

Chronic pain, including vestibulodynia (VBD), presents diagnostic and treatment challenges due to unclear causes and varied symptoms.
MicroRNAs (miRNAs) are increasingly recognized for their role in regulating pain-associated genes, but their specific involvement in chronic pain conditions remains underexplored.

Purpose of the Study:

To investigate the relationship between pain, psychological factors, plasma cytokines, and whole blood miRNA expression in healthy controls (HCs), VBD patients, and VBD patients with irritable bowel syndrome (VBD + IBS).
To identify potential miRNA biomarkers that differentiate VBD subtypes and inform treatment strategies.

Main Methods:

Comparative analysis of self-reported pain, psychological profiles, plasma cytokine levels, and whole blood miRNA expression across three groups: HCs, VBD, and VBD + IBS.
Statistical analysis to correlate miRNA expression with clinical pain phenotypes and cytokine levels.

Main Results:

VBD + IBS subjects reported worse health, function, and increased somatic pain compared to HCs and VBD subjects.
VBD + IBS subjects showed an imbalance in cytokine profiles, lacking a compensatory anti-inflammatory response.
Distinct miRNA expression profiles were observed in VBD and VBD + IBS groups compared to HCs, with specific miRNAs implicated in pain, estrogen signaling, cell physiology, and insulin signaling.

Conclusions:

MicroRNA expression patterns differ significantly between VBD and VBD + IBS, suggesting distinct underlying biological mechanisms.
miRNAs hold promise as biomarkers for distinguishing between localized VBD and VBD with central pain contributions, potentially guiding personalized treatment approaches.