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Published on: January 14, 2014
Arteriovenous malformation within an isocitrate dehydrogenase 1 mutated anaplastic oligodendroglioma
Grace Lai1, Karra A Muller2, Bob S Carter3
1School of Medicine, University of California, San Diego, CA, USA.
Background:
The co-occurrence of intracranial arteriovenous malformations (AVMs) and cerebral neoplasms is exceedingly rare but may harbor implications pertaining to the molecular medicine of brain cancer pathogenesis.
Case Description:
Here, we present a case of de novo AVM within an isocitrate dehydrogenase 1 mutated anaplastic oligodendroglioma (WHO Grade III) and review the potential contribution of this mutation to aberrant angiogenesis as an interesting case study in molecular medicine.
Conclusion:
The co-occurrence of an IDH1 mutated neoplasm and AVM supports the hypothesis that IDH1 mutations may contribute to aberrant angiogenesis and vascular malformation.
