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Malignant Eccrine Spiradenoma of the Face
Theodore T Nyame1, David Mattos, Christine G Lian
1*Division of Plastic Surgery †Division of Dermatopathology, Department of Pathology, Harvard Medical School, Brigham and Women's Hospital, Boston, MA.
The Journal of Craniofacial Surgery
|July 14, 2015
Summary
Malignant eccrine spiradenoma, a rare sweat gland tumor, can present as low-grade carcinoma. This case highlights a rare instance of malignant transformation in benign spiradenomas, offering insights for recognition and treatment.
Area of Science:
- Dermatopathology
- Oncology
Background:
- Malignant eccrine spiradenoma (spiradenocarcinoma) is an exceptionally rare sweat gland tumor.
- Low-grade malignant variants are even rarer, with limited understanding of their behavior and established treatments.
Observation:
- A case of a 29-year-old woman with a long history of facial lesions since infancy is presented.
- Histopathologic examination revealed multiple benign spiradenomas with foci of low-grade malignant transformation.
Findings:
- The malignant transformation was characterized by the loss of the typical two-cell population seen in benign spiradenomas.
- This case contributes to the limited literature on the histopathology of low-grade malignant eccrine spiradenoma.
Implications:
- The report aims to guide the recognition of this rare entity based on clinical presentation and histopathologic findings.
- Further understanding of low-grade malignant eccrine spiradenoma is crucial for developing evidence-based therapeutic strategies.
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