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Updated: Apr 7, 2026
The Quantification of Injectability by Mechanical Testing
Published on: May 13, 2020
Preparation and characterization of a novel injectable strontium-containing calcium phosphate cement with collagen
Zi-Qiang Zhou1, Dong-Ping Ye, Wei-Guo Liang
1Guang Zhou Red Cross Hospital, The Fourth Affiliated Hospital of the Medical College, Jinan University, Guangzhou 510220, China.
Purpose:
To develop a novel injectable strontium-containing calcium phosphate cement with collagen.
Methods:
A novel calcium phosphate bone cement (CPC) was prepared with the addition of strontium element, collagenl, and modified starch; the injectability, solidification time, microstructure, phase composition, compressive strength, anti-collapsibility and histological properties of material were evaluated.
Results:
The results showed that the material could be injected with an excellent performance; the modified starch significantly improved the anti-washout property of cement; with the liquid to solid ratio of 0.3, the largest compressive strength of cement was obtained (48.0 MPa ± 2.3 MPa); histological examination of repair tissue showed that the bone was repaired after 16 weeks; the degradation of cement was consistent with the new bone growth.
Conclusion:
A novel injectable collagen-strontium-containing CPC with excellent compressive strength and suitable setting time was prepared, with addition of modified starch. The CPC showed a good anti-washout property and the degradation time of the cement met with the new bone growing. This material is supposed to be used in orthopedic and maxillofacial surgery for bone defects.
