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Updated: Aug 18, 2026

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
Published on: October 11, 2018
Misclassification in more than one factor in a case-control study: a combination of Mantel-Haenszel and maximum
Abstract:
Misclassification can arise in the case-control setting in both the risk factor of interest, and in a potential confounder. If true status is not ascertainable, but an independent replicated sample is available, adjusted maximum likelihood estimates of the individual binomial proportions can be obtained, and hence a relative risk estimate of the Mantel-Haenszel type constructed. An interval estimate on the latter can be calculated using the asymptotic properties of the likelihood function. The method is illustrated by application to a case-control study of breast cancer risk and such lifestyle attributes as diet, smoking and alcohol consumption, in which misclassification was anticipated and consequently repeatability data were collected.
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