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[Peritonitis in intermittent peritoneal dialysis: microbiological aspects and the antibiogram]
Revista Do Hospital Das Clinicas
|May 1, 1989
Summary
Peritonitis in peritoneal dialysis patients is often bacterial. Staphylococcus species are common, showing sensitivity to vancomycin and netilmicin, but resistance to ampicillin.
Area of Science:
- Microbiology
- Nephrology
- Infectious Diseases
Context:
- Peritonitis is a frequent complication for patients undergoing peritoneal dialysis.
- Bacterial infections are the primary cause of peritonitis in this population.
- Effective initial antibiotic therapy requires understanding local microbial patterns and sensitivities.
Purpose:
- To analyze the microbiological profiles of bacteria causing peritonitis in peritoneal dialysis patients.
- To determine the antibiotic sensitivity patterns of isolated microorganisms.
- To inform optimal empirical antibiotic selection for peritonitis treatment.
Summary:
- This study examined 503 peritoneal dialysis effluent cultures, identifying microorganisms in 52 instances.
- Staphylococcus aureus and Staphylococcus epidermidis were the most prevalent bacteria (29% each).
- High sensitivity was observed for netilmicin, amikacin, and later-generation cephalosporins, while resistance to ampicillin, co-trimoxazole, cephalothin, and gentamicin was noted.
Impact:
- Findings highlight the importance of characterizing causative organisms and their antibiotic susceptibilities for effective peritonitis management.
- Results guide the selection of appropriate initial antibiotic regimens, potentially improving patient outcomes.
- Understanding resistance patterns is crucial for antimicrobial stewardship in peritoneal dialysis.