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Reversible dementia: two nursing home patients with voltage-gated potassium channel antibody-associated limbic
Wesley Reintjes1, Marloes D M Romijn1, Daan Hollander2
1Department of Geriatric Medicine, Jeroen Bosch ziekenhuis, Den Bosch, The Netherlands.
Abstract:
Voltage-gated potassium channel antibody-associated limbic encephalitis (VGKC-LE) is a rare disease that is a diagnostic and therapeutic challenge for medical practitioners. Two patients with VGKC-LE, both developing dementia are presented. Following treatment, both patients showed remarkable cognitive and functional improvement enabling them to leave the psychogeriatric nursing homes they both were admitted to. Patients with VGKC-LE can have a major cognitive and functional improvement even after a diagnostic delay of more than 1 year. Medical practitioners who treat patients with unexplained cognitive decline, epileptic seizures, or psychiatric symptoms should be aware of LE as an underlying rare cause.
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