Ordered mesoporous silica modified with lanthanum for ibuprofen loading and release behaviour.

Area of Science:

• Materials Science
• Nanotechnology
• Pharmaceutical Science

Background:

• Ordered mesoporous silicas like SBA-15 and KIT-6 are widely studied for their unique structural properties.
• Lanthanum modification is explored to enhance the functionality of these silica materials.
• Ibuprofen delivery systems are crucial in pharmaceutical applications.

Purpose of the Study:

• To investigate the adsorption and release of ibuprofen using lanthanum-modified SBA-15 and KIT-6 silicas.
• To understand the effect of lanthanum loading on the structural and textural properties of these silicas.
• To evaluate the correlation between silica properties and ibuprofen storage/release performance.

Main Methods:

• Hydrothermal synthesis of SBA-15 and KIT-6 using Pluronic P123 template.
• Impregnation with lanthanum(III) chloride to achieve 1, 3, and 5 wt.% La loading.
• Characterization using X-ray diffraction, transmission electron microscopy, UV-Vis spectrophotometry, and nitrogen sorption.
• Assessment of ibuprofen adsorption and release kinetics.

Main Results:

• Lanthanum modification significantly altered the structural and textural properties of SBA-15 and KIT-6.
• Ibuprofen storage capacity increased with higher lanthanum content and larger pore diameters.
• KIT-6 silica exhibited higher ibuprofen adsorption compared to SBA-15.
• Increased lanthanum coverage enhanced both the amount and rate of ibuprofen release.

Conclusions:

• Lanthanum-modified mesoporous silicas are effective materials for ibuprofen adsorption and release.
• The properties of SBA-15 and KIT-6 can be tailored by lanthanum modification for drug delivery applications.
• These materials offer potential for controlled release of pharmaceuticals.