Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease of serum immunoglobulin M levels in some diabetic patients.

D Cheţa1, G Stoica, N Cheţa

  • 1Clinic of Diabetes, Nutrition and Metabolic Diseases, Bucharest, Romanìa.

Medecine Interne
|July 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does point-of-care ultrasonography improve diagnostic accuracy in emergency department patients with undifferentiated hypotension? An international randomized controlled trial from the SHOC-ED investigators.

CJEM·2022
Same author

Sleep and Memory Disorders in a Patient Suffering from Charcot-Marie-Tooth Disease.

Current health sciences journal·2019
Same author

Phenotypic spectrum and hormonal profile in hypogonadotropic hypogonadism.

Journal of medicine and life·2014
Same author

The growth of the canine glioblastoma cell line D-GBM and the canine histiocytic sarcoma cell line DH82 is inhibited by the resveratrol oligomers hopeaphenol and r2-viniferin.

Veterinary and comparative oncology·2012
Same author

[Preventive and emergency embolization of angiomyolipomas: our experience].

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2011
Same author

Expression of a 65 kda oncofetal phosphoprotein in the altered hepatic foci of rats fed 2-acetylaminofluorene followed by phenobarbital.

International journal of oncology·2011

Serum immunoglobulin M (IgM) levels are lower in juvenile and non-insulin-dependent diabetes mellitus (NIDDM) patients. These reduced IgM levels may contribute to increased infection susceptibility in some individuals with diabetes.

Area of Science:

  • Immunology
  • Endocrinology
  • Metabolic Diseases

Background:

  • Conflicting findings exist regarding serum immunoglobulin levels in diabetic populations.
  • Serum IgM levels are known to be influenced by age and sex.

Purpose of the Study:

  • To investigate serum IgM levels in different types of diabetes mellitus (DM).
  • To determine if altered IgM levels correlate with diabetes type and infection susceptibility.

Main Methods:

  • Serum IgM was measured using standardized endpoint radial immunodiffusion.
  • Z-scores for IgM levels were calculated, adjusting for age and sex using established reference data.
  • Statistical analysis, including Z-score comparisons and chi-square tests, was performed.

Related Experiment Videos

Main Results:

  • Juvenile insulin-dependent diabetes mellitus (IDDM) and NIDDM patients exhibited significantly lower serum IgM Z-scores compared to controls.
  • Adult-onset IDDM patients did not show a significant difference in IgM levels compared to controls.
  • The distribution of diabetes prevalence across IgM quartiles was significantly different from expected, particularly for juvenile IDDM and NIDDM.

Conclusions:

  • Lower serum IgM levels are associated with juvenile IDDM and NIDDM.
  • Reduced IgM may be a contributing factor to the increased susceptibility to infections observed in some diabetic patients.
  • Further research is warranted to elucidate the role of IgM in diabetic complications.