Sleep and Memory Disorders in a Patient Suffering from Charcot-Marie-Tooth Disease

Area of Science:

• Neurology
• Genetics

Background:

• Charcot-Marie-Tooth (CMT) disease is the most prevalent inherited neurological disorder, currently without a cure.
• The primary genetic cause is PMP22 gene duplication on chromosome 17.
• CMT affects a small but significant portion of the population.

Purpose of the Study:

• To report a unique case of Charcot-Marie-Tooth disease presenting with cognitive and sleep disturbances.
• To explore the potential interplay between CMT, diabetes mellitus, and associated complications.

Main Methods:

• Case report of a 37-year-old male patient diagnosed with CMT.
• Clinical assessment including neurological examination and review of medical history.
• Analysis of patient's comorbidities, specifically diabetes mellitus.

Main Results:

• The patient exhibited sleep, memory, and attention deficits, including early-onset retrograde amnesia.
• No family history of genetic disease was reported.
• The patient was diagnosed with diabetes mellitus, correlating with sensory loss and prolonged infections.

Conclusions:

• This case underscores the diverse clinical manifestations of CMT, extending beyond peripheral neuropathy to include cognitive and sleep disorders.
• The presence of diabetes mellitus exacerbates sensory symptoms and increases susceptibility to infections with delayed healing in CMT patients.
• Further research is warranted to understand the complex relationship between CMT, diabetes, and neurological function.