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Updated: Apr 7, 2026

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
Published on: June 8, 2022
A novel jaspine B-ceramide hybrid modulates sphingolipid metabolism
Virginie Garcia1, Pauline Le Faouder2, Aude Dupuy2
1INSERM UMR1037, CRCT (Centre de Recherches en Canćerolgie de Toulouse), Oncopole de Toulouse, 2, avenue Hubert Curien, CS 53717, 31037 Toulouse cedex 1.
Abstract:
A new sphingolipid hybrid molecule was designed to assemble, within a tail-to-tail double-chain structure, the ceramide hydrophilic moiety and the tetrahydrofuran pharmacophore of jaspine B, a natural product known to interfere with sphingolipid metabolism. This compound was prepared through acylation of sphingosine with a jaspine B derivative bearing a COOH group in the terminal position of the aliphatic backbone. This new hybrid molecule was evaluated for its capacities to affect melanoma cell viability and sphingolipid metabolism. While retaining the cytotoxicity of ceramide itself, this compound was shown to lower the sphingomyelin cellular levels and significantly enhance the production of sphingosine-1-phosphate, thus representing a novel sphingolipid metabolism modulator.
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