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Related Concept Videos

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Related Experiment Video

Updated: Apr 7, 2026

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis
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Decrease of oxidative phosphorylation system function in severe septic patients.

Leonardo Lorente1, María M Martín2, Ester López-Gallardo3

  • 1Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s/n La Laguna, 38320, Santa Cruz de Tenerife, Spain.

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|July 16, 2015
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Severe sepsis patients exhibit reduced platelet complex IV activity compared to healthy individuals. This finding, observed in the largest study to date, highlights impaired mitochondrial function in sepsis.

Keywords:
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Area of Science:

  • Biochemistry
  • Critical Care Medicine
  • Mitochondrial Biology

Background:

  • Oxidative phosphorylation system (OPS) capacity in sepsis is understudied, particularly in large patient cohorts.
  • Previous studies with small sample sizes have limited insights into OPS function in septic patients.

Purpose of the Study:

  • To compare platelet respiratory complex IV (CIV) activity between severe septic patients and healthy controls.
  • To analyze OPS capacity in a large series of 198 severe septic patients and 96 healthy controls.

Main Methods:

  • Prospective, multicenter, observational study across 6 Spanish intensive care units.
  • Platelet CIV-specific activity measured in 198 severe septic patients (days 1, 4, 8) and 96 controls.
  • 30-day mortality served as the study's primary endpoint.

Main Results:

  • Healthy controls displayed significantly higher platelet CIV-specific activity than both surviving and nonsurviving septic patients.
  • This difference was consistent across days 1, 4, and 8 of severe sepsis diagnosis.
  • P < .001 indicated statistical significance.

Conclusions:

  • Septic patients, both survivors and nonsurvivors, demonstrated lower platelet CIV-specific activity during the first week of sepsis compared to healthy individuals.
  • This study represents the largest series to date examining OPS capacity in severe sepsis.
  • Reduced platelet CIV activity may serve as a biomarker for impaired mitochondrial function in sepsis.