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The Oral Microbiota01:27

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
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The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...

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Related Experiment Video

Updated: May 11, 2026

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Association Between Salivary Sirtuin-1 Levels and Periodontitis.

Leonardo Lorente1, Esther Hernández Marrero2, Pedro Abreu González3

  • 1Intensive Care Unit, Hospital Universitario de Canarias, Ofra s/n, 38320 San Cristóbal de La Laguna, Tenerife, Spain.

Journal of Clinical Medicine
|February 27, 2026
PubMed
Summary
This summary is machine-generated.

Low salivary Sirtuin-1 (SIRT-1) concentrations may indicate periodontitis. This study found lower SIRT-1 levels in periodontitis patients, suggesting a potential role in diagnosis, though further research is needed.

Keywords:
oxidationperiodontitissalivarysirtuin-1

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Area of Science:

  • Biochemistry
  • Oral Health
  • Aging Research

Background:

  • Sirtuin-1 (SIRT-1) is an enzyme with antioxidant, anti-inflammatory, and anti-apoptotic properties, influencing aging and age-related diseases.
  • Previous studies on salivary SIRT-1 in periodontitis were limited by small sample sizes and found no significant differences.
  • This research addresses the gap by investigating salivary SIRT-1 in a larger cohort.

Purpose of the Study:

  • To compare salivary SIRT-1 concentrations between periodontitis patients and healthy subjects.
  • To determine the association between salivary SIRT-1 levels and periodontitis.
  • To evaluate the diagnostic potential of salivary SIRT-1 for periodontitis.

Main Methods:

  • A cross-sectional study involving 144 participants (59 with periodontitis, 85 without).
  • Salivary SIRT-1 concentrations were measured.
  • Multivariate logistic regression and receiver operating characteristic (ROC) analysis were employed.

Main Results:

  • Low salivary SIRT-1 concentrations (< 1.2 ng/mL) were independently associated with periodontitis (OR = 2.84, p = 0.04).
  • ROC analysis indicated a diagnostic capability of 74% for periodontitis (p < 0.001).
  • This study included the largest sample size to date for salivary SIRT-1 in periodontitis patients.

Conclusions:

  • Low salivary SIRT-1 concentrations may be linked to the presence of periodontitis.
  • Salivary SIRT-1 shows potential as an adjunctive diagnostic marker for periodontitis.
  • Further research is required to validate these preliminary findings due to study limitations.