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Neutrophil CD64 Expression as a Diagnostic Marker in Patients Hospitalized with Exacerbations of COPD: A Prospective

Elena Titova1,2, Marthe Wedø Aune3, Kristin Fonn4

  • 1Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, 7006, Trondheim, Norway. elena.titova@ntnu.no.

Lung
|July 16, 2015
PubMed

Insights

Neutrophil CD64 expression shows similar diagnostic accuracy to C-reactive protein (CRP) for pneumonia in COPD exacerbations. CD64 does not improve diagnosis when combined with CRP and white blood cell count (WBC).

Area of Science:

  • Clinical diagnostics
  • Immunology
  • Respiratory medicine

Background:

  • Neutrophil CD64 expression is a potential marker for bacterial infections and sepsis.
  • Accurate diagnosis of pneumonia in acute exacerbations of COPD (AECOPD) is crucial.

Purpose of the Study:

  • To compare the diagnostic accuracy of CD64 with CRP and WBC for pneumonia in AECOPD patients.
  • To evaluate the expression kinetics of CD64 during AECOPD hospitalization.

Main Methods:

  • Prospective, single-centre observational study.
  • Blood samples collected at admission and 6, 24, 48 hours post-admission.
  • CD64 measured using Leuko64 kit; CRP and WBC analyzed. ROC curve analysis used for diagnostic accuracy comparison.

Main Results:

  • 113 patients included; 32% had pulmonary infiltrate (PI).
  • CD64 expression was significantly higher in patients with PI (median 1.25 vs. 0.60, p=0.002).
  • Area under ROC curve: CD64 (0.69), CRP (0.73), WBC (0.64); no significant difference (p=0.42).

Conclusions:

  • CD64 expression has comparable diagnostic accuracy to CRP for pneumonia in AECOPD.
  • CD64 does not enhance diagnostic accuracy beyond CRP and WBC in this patient group.
Abstract

Keywords:
BiomarkersCOPD exacerbationDiagnostic accuracyInfectionNeutrophil CD64 expression

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