Related Experiment Video

Updated: Aug 3, 2026

Prehospital Thrombolysis: A Manual from Berlin
05:52

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 26, 2013

22.5K

Is Aspiration Thrombectomy Beneficial in Patients Undergoing Primary Percutaneous Coronary Intervention?

Islam Y Elgendy1, Tianyao Huo1, Deepak L Bhatt1

  • 1From the Department of Medicine, University of Florida, Gainesville (I.Y.E., T.H., A.A.B.); Department of Medicine, Brigham and Women's Hospital Heart and Vascular Center, Harvard Medical School, Boston, MA (D.L.B.); and Medicine Service, North Florida/South Georgia Veterans Health System, Gainesville (A.A.B.).

Circulation. Cardiovascular Interventions
|July 16, 2015
PubMed

Insights

Aspiration thrombectomy before primary percutaneous coronary intervention (PCI) offers no clinical benefit for ST-segment-elevation myocardial infarction patients and may increase stroke risk. Glycoprotein IIb/IIIa inhibitors and ischemic time did not alter these outcomes.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Clinical Trials

Background:

  • Uncertainty exists regarding the impact of intravenous glycoprotein IIb/IIIa inhibitors and ischemic time on the efficacy of aspiration thrombectomy preceding primary percutaneous coronary intervention (PCI) in ST-segment-elevation myocardial infarction (STEMI) patients.
  • Aspiration thrombectomy is a procedure to remove blood clots from coronary arteries.

Purpose of the Study:

  • To evaluate the clinical benefits and risks of aspiration thrombectomy before primary PCI in STEMI patients.
  • To investigate whether intravenous glycoprotein IIb/IIIa inhibitors or ischemic time modify the clinical outcomes of aspiration thrombectomy.

Main Methods:

  • A systematic review and meta-analysis of randomized controlled trials comparing aspiration thrombectomy followed by primary PCI versus conventional primary PCI in STEMI patients.
  • Seventeen trials involving 20,960 patients were analyzed using a DerSimonian-Laird model to calculate summary estimates.

Main Results:

  • Aspiration thrombectomy did not significantly reduce the risk of mortality (2.8% vs 3.2%), reinfarction (1.3% vs 1.4%), or the combined outcome of mortality or reinfarction (4.1% vs 4.6%) compared to conventional PCI.
  • The procedure was associated with a nonsignificant increase in stroke risk (0.6% vs 0.4%).
  • Meta-regression analysis revealed no significant influence of intravenous glycoprotein IIb/IIIa inhibitors or ischemic time on the observed outcomes.

Conclusions:

  • Aspiration thrombectomy before primary PCI is not associated with improved clinical end points in STEMI patients.
  • The procedure may potentially increase the risk of stroke.
  • Concomitant use of glycoprotein IIb/IIIa inhibitors and varying ischemic times did not appear to modify the clinical benefits of aspiration thrombectomy.
Abstract

Keywords:
meta-analysismyocardial infarctionpercutaneous coronary interventionstrokethrombectomy

More Related Videos

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function10:28

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Published on: March 15, 2022

6.2K
Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels08:12

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels

Published on: May 26, 2023

2.8K

Related Concept Videos

Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...