Related Experiment Video
Updated: Apr 7, 2026

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
Published on: February 7, 2018
Dietary antioxidant synergy in chemical and biological systems
1a Canadian Food and Wine Institute, Niagara College , Niagara-on-the-Lake , Ontario , Canada.
Abstract:
Antioxidant (AOX) synergies have been much reported in chemical ("test-tube" based assays focusing on pure chemicals), biological (tissue culture, animal and clinical models), and food systems during the past decade. Tentative synergies differ from each other due to the composition of AOX and the quantification methods. Regeneration mechanism responsible for synergy in chemical systems has been discussed. Solvent effects could contribute to the artifacts of synergy observed in the chemical models. Synergy in chemical models may hardly be relevant to biological systems that have been much less studied. Apparent discrepancies exist in understanding the molecular mechanisms in both chemical and biological systems. This review discusses diverse variables associated with AOX synergy and molecular scenarios for explanation. Future research to better utilize the synergy is suggested.
Related Concept Videos
Radical Autoxidation
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Bioactivation and Tissue Toxicity
Oxidation of Phenols to Quinones
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
Redox Reactions
Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...

