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Related Concept Videos

Centrifugation01:05

Centrifugation

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Centrifugation is a separation technique based on differences in density or size. It is commonly used to separate solids from aqueous interferents. During centrifugation, the sample is placed in centrifugation tubes and spun at high angular velocity, which allows centrifugal force to act differentially on the different densities or masses of the components. After spinning, the supernatant liquid is decanted. Depending on the specific application, either the pellet or the supernatant is retained...
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Erythrocyte Sedimentation Rate: A Physics-Driven Characterization in a Medical Context
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Mesoscale blood cell sedimentation for processing millilitre sample volumes.

C Galligan1, J Nichols, E Kvam

  • 1Electrical Technology Systems Organization, General Electric Global Research Centre. 1 Research Circle, Niskayuna, NY, 12308 USA. puleo@ge.com.

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|July 17, 2015
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Summary

This study presents a simple gravity sedimentation device for rapid blood cell separation from millilitre volumes. The technology overcomes limitations in point-of-care diagnostics by efficiently separating cells from whole blood samples.

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Area of Science:

  • Biomedical Engineering
  • Clinical Diagnostics
  • Point-of-Care Testing

Background:

  • Blood cell and plasma separation is crucial for clinical diagnostics.
  • Current separation techniques face challenges in sample volume and throughput, hindering point-of-care applications.
  • Reliable and efficient separation methods are needed for remote and point-of-care diagnostic success.

Purpose of the Study:

  • To develop an efficient method for separating blood cells from millilitre volumes of whole blood.
  • To address the limitations of existing plasma collection devices that rely on microchannels.
  • To enable rapid and high-throughput blood sample processing for diagnostics.

Main Methods:

  • Utilized a simple gravity sedimentation device.
  • Employed a hybrid micro/mesoscale sedimentation chamber.
  • Tested with millilitre volumes of whole blood.

Main Results:

  • Achieved efficient separation of blood cells from whole blood in minutes.
  • Demonstrated >99% capture of cells from millilitre blood samples.
  • Completed separation in less than two minutes, overcoming microchannel limitations.

Conclusions:

  • The gravity sedimentation device offers an efficient solution for blood cell separation.
  • This technology has the potential to advance point-of-care and remote diagnostics.
  • The hybrid micro/mesoscale chamber enables high-throughput processing of larger sample volumes.