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Exploring the diagnosis markers for gallbladder cancer based on clinical data
Lingqiang Zhang1, Runchen Miao, Xiude Zhang
1Department of Hepatobiliary Surgery, the First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, 710061, China.
Frontiers of Medicine
|July 17, 2015
Summary
This study identified key indicators for gallbladder cancer (GBC) diagnosis. Age, gender, gallstones, alkaline phosphatase (ALP), total bilirubin (TB), and CA125 are significant risk factors for GBC.
Area of Science:
- Oncology
- Biochemistry
- Medical Diagnostics
Background:
- Gallbladder cancer (GBC) lacks effective diagnostic markers.
- Early and accurate diagnosis is crucial for improving patient outcomes.
Purpose of the Study:
- To explore and validate potential diagnostic markers for GBC.
- To identify independent risk factors associated with GBC development.
Main Methods:
- Retrospective review of clinical data from 144 GBC patients and 116 cholelithiasis patients.
- Logistic regression analysis to determine independent risk factors.
- Receiver operating characteristic (ROC) curve analysis to assess diagnostic value of identified factors.
Main Results:
- Significant differences observed in age, gender, gallstones, total bilirubin (TB), alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), platelet count (PLT), CA125, and CA199 between GBC and cholelithiasis groups.
- Independent risk factors for GBC identified: age, gender, gallstones, ALP, TB, and CA125.
- CA125 (AUC=0.720), ALP (AUC=0.713), TB (AUC=0.636), and age (AUC=0.573) demonstrated diagnostic value.
Conclusions:
- Age, TB, ALP, and CA125 serve as valuable auxiliary diagnostic factors for GBC.
- A GBC diagnostic model integrating these factors provides a quantitative tool for clinical assessment.
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