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Modeling for (physical) biologists: an introduction to the rule-based approach

Lily A Chylek1, Leonard A Harris, James R Faeder

  • 1Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA. Theoretical Biology and Biophysics Group, Theoretical Division and Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

Physical Biology
|July 17, 2015
PubMed
Summary

Rule-based modeling captures cellular chemical kinetics by defining generalized biomolecular interactions. This approach allows detailed analysis of how component properties influence system-level behaviors in regulatory networks.

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