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Updated: Feb 11, 2026

A Simple Cell-based Immunofluorescence Assay to Detect Autoantibody Against the N-Methyl-D-Aspartate NMDA Receptor in Blood
Published on: January 9, 2018
[Safety of plasma exchange therapy in patients with anti-NMDA receptor encephalitis]
Yan Zhang1, Daiquan Gao2, Hong Ye2
1Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China;
Objective:
To explore the safety of plasma exchange (PE) therapy in patients with anti-NMDA receptor encephalitis.
Methods:
Prospective reviews were conducted for the adverse events and therapeutic efficacies of PE therapy in 9 patients with anti-NMDA receptor encephalitis admitted into neuro-intensive care unit from January 2012 to January 2015.
Results:
A total of 54 PE procedures were performed. The NMDA receptor antibody titer of cerebrospinal fluid (CSF) and/or sera in 9 patients (100%) decreased or turned negative. Five patients (55.5%) demonstrated clinical improvement after PE therapy. And clinical complications included frequent involuntary movements, hypotension, coagulation of PE channel, febricity, allergic response and errhysis around peripheral venous access.
Conclusion:
PE is effective, safe and well-tolerated in patients with anti-NMDA receptor encephalitis.
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