Polysaccharide-porphyrin-fullerene supramolecular conjugates as photo-driven DNA cleavage reagents
1Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China. yuliu@nankai.edu.cn.
Abstract:
Two water-soluble polysaccharide-porphyrin-fullerene supramolecular conjugates were constructed from the non-covalent incorporation of triphenyl Zn-porphyrin-modified β-cyclodextrins, adamantyl-modified hyaluronate and C60. Significantly, these supramolecular conjugates, which exist as cross-linked or discrete nanoparticles with a diameter of 50-200 nm, can completely cleave closed supercoiled DNA to nicked DNA under light irradiation.


