Related Experiment Video
Updated: Apr 7, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Modeling of Dopamine D2 Receptor - Overview of 35-Year Evolution
Vladimir Sukalovic, Vukic Soskic, Sladjana Kostic-Rajacic1
1ORGENTEC Diagnostika GmbH, Carl-Zeiss-Str. 49, 55129 Mainz, Germany. vukic.soskic@gmail.com.
This review details the evolution of dopamine D2 receptor models over 35 years. Advances in structural biology and computational chemistry enabled detailed models, aiding new drug development for dopamine system imbalances.
Area of Science:
- Neuroscience
- Pharmacology
- Structural Biology
Background:
- Dopamine (DA) and its receptors, particularly the D2 receptor subclass, have been a focus of intense research for 35 years.
- Early models of dopamine receptors (DRs) were limited by sparse experimental data.
Purpose of the Study:
- To review key discoveries in the development of the D2 DR receptor model.
- To highlight the impact of structural and computational biology on understanding DRs.
Main Methods:
- Medicinal chemistry
- Molecular and structural biology
- Computational chemistry
Main Results:
- Availability of crystal structures for related proteins and the D3 DR receptor facilitated improved D2 DR receptor models.
- New models provide insights into ligand-receptor interactions.
Conclusions:
- Detailed D2 DR receptor models are crucial for understanding dopamine system function.
- These models pave the way for synthesizing novel dopaminergic compounds and potential therapeutics for neurological disorders.
More Related Videos
07:41Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0
Published on: June 5, 2017
07:25Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology
Published on: March 27, 2018
Related Concept Videos
The Two-State Receptor Model
The binding affinity of a drug determines its interaction with...
G Protein-coupled Receptors
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
Quantitative Aspects of Drug-Receptor Interaction
Pharmacodynamic Models: Overview
Drug-Receptor Bonds
In...
Transducer Mechanism: G Protein–Coupled Receptors
GPCRs are also called heptahelical,...