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[Chronotherapy in arterial hypertension]

M Bendersky1

  • 1Departamento de Farmacología Aplicada, Universidad Nacional de Córdoba, Córdoba, Argentina.

Hipertension Y Riesgo Vascular
|July 17, 2015
PubMed

Insights

Understanding blood pressure (BP) changes, like the morning BP surge, is key for cardiovascular and cerebrovascular risk. Ambulatory blood pressure monitoring (ABPM) aids in optimizing drug timing for better patient outcomes.

Area of Science:

  • Cardiology
  • Neurology
  • Pharmacology

Background:

  • Blood pressure (BP) profiles in normotensive and hypertensive individuals are established.
  • The impact of BP variations on cardio- and cerebrovascular risk is known.
  • Ambulatory blood pressure monitoring (ABPM) has significantly advanced BP parameter knowledge.

Purpose of the Study:

  • To investigate the correlation between specific BP profile components and patient risk.
  • To explore the potential of chronotherapy guided by ABPM data.
  • To highlight the need for further research into BP modifications for risk prevention.

Main Methods:

  • Utilizing ambulatory blood pressure monitoring (ABPM) to analyze BP fluctuations.
  • Focusing on specific BP components, including nocturnal decrease and morning BP surge.
  • Reviewing existing data and identifying gaps in current research.

Main Results:

  • ABPM provides crucial insights into BP variability.
  • The nocturnal BP decrease and morning BP surge are identified as key risk indicators.
  • Current research on modifying these BP components for risk reduction is limited.

Conclusions:

  • Optimizing drug administration timing (chronotherapy) based on ABPM data may mitigate risks.
  • Further multicenter studies are essential to confirm the preventive impact of BP modifications.
  • Targeting specific BP dynamics holds promise for improved cardiovascular and cerebrovascular risk management.

Keywords:
Ascenso matinalBlood pressure morning surgeChronotherapyCircadian rythm of BPCronoterapiaNocturnal blood pressurePresión nocturnaRitmo circadiano de la presión

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