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Related Concept Videos

Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
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Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

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Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
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Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

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In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
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Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
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Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

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Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
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Updated: Apr 7, 2026

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
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A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice

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Paediatric pancreatitis.

John F Pohl1, Aliye Uc

  • 1aDepartment of Pediatric Gastroenterology, Primary Children's Hospital, University of Utah School of Medicine, Salt Lake City, Utah bDepartment of Pediatric Gastroenterology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.

Current Opinion in Gastroenterology
|July 17, 2015
PubMed
Summary
This summary is machine-generated.

Recent studies show paediatric pancreatitis incidence rivals adults, yet guidelines are lacking. Genetic factors and congenital issues are key risks for recurrent and chronic pancreatitis in children, demanding a unified research approach.

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Area of Science:

  • Pediatric Gastroenterology
  • Pancreatology

Background:

  • Paediatric pancreatitis incidence is rising, approaching adult levels.
  • Lack of established diagnostic and treatment guidelines for children.
  • Significant socioeconomic burden associated with chronic pancreatitis in children.

Purpose of the Study:

  • To review recent advancements in paediatric pancreatitis.
  • To discuss the causes of paediatric pancreatitis.
  • To outline current management strategies for paediatric pancreatitis.

Main Methods:

  • Literature review of recent studies on paediatric pancreatitis.
  • Analysis of risk factors, including genetic and structural abnormalities.
  • Evaluation of current medical and surgical treatment options.

Main Results:

  • Genetic and congenital abnormalities are primary risk factors for recurrent and chronic pancreatitis in children.
  • Limited evidence supports the efficacy of current medical and surgical therapies for paediatric chronic pancreatitis.
  • Paediatric pancreatitis poses significant health challenges, with limited supporting data.

Conclusions:

  • Acute recurrent and chronic pancreatitis present major health concerns for children.
  • Existing therapies for paediatric pancreatitis lack robust supporting data due to small cohorts.
  • A multidisciplinary, multicentre approach is crucial for advancing understanding and treatment of paediatric pancreatic diseases.