[Local tissue changes in venous ulcers of the leg]

Authors investigated anaerobic metabolites (lactate, pyruvate), gas analyzes, pathohistological changes (light and electron microsc.) and regulatory agents in the local blood of venous ulcers. The cause of anaerobic disturbance is hypoxia and hypercapnia (hypostatic ulcers) and pathologic vasodilatation and arteriolo-venules shunts (postthrombotic ulcers). Pericapillary fibrin deposition aggravate tissue necrosis and destructions.