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Updated: Apr 6, 2026

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats
Published on: December 13, 2019
Resonant cardiac chamber with diastolic thrill
Hirofumi Kurokawa1, Ikuo Misumi, Tsuyoshi Honda
1Department of Cardiology, Kumamoto Saisyunsou Hospital, 2659, Suya, Koshi, Kumamoto, 861-1196, Japan.
Severe aortic regurgitation can cause a distinct thrill by inducing basal septal vibration. This case highlights a unique echocardiographic finding in a 70-year-old man with a significant heart murmur.
Area of Science:
- Cardiology
- Echocardiography
- Cardiac Mechanics
Background:
- A 70-year-old male presented with a severe diastolic heart murmur (Levine V/VI).
- The patient exhibited symptoms suggestive of significant valvular dysfunction.
Observation:
- Doppler color-flow imaging revealed eccentric severe aortic regurgitation.
- M-mode echocardiography showed anterior mitral leaflet fluttering and aortic root tremors.
- Curved M-mode myocardial strain rate imaging demonstrated massive basal septal vibration during diastole.
Findings:
- The observed basal septal vibration is a novel echocardiographic finding.
- The regurgitant flow's force is hypothesized to be the cause of the septal vibration.
- This vibration may manifest as a palpable thrill.
Implications:
- This case expands the understanding of the physical manifestations of severe aortic regurgitation.
- Echocardiography, particularly advanced M-mode techniques, can reveal subtle mechanical effects of valvular disease.
- The findings suggest a potential mechanism linking hemodynamic forces to palpable physical signs in cardiac pathology.
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