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Updated: Apr 6, 2026

Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma
Published on: April 15, 2022
Follicular lymphoma (in situ) pattern in the bone marrow: does it indicate an early stage in disease evolution?
Bachir Alobeid1, John Gregory Mears2, Govind Bhagat1
1Division of Hematopathology, Department of Pathology and Cell Biology, Columbia University Medical Center-New York Presbyterian Hospital New York City, New York.
Abstract:
Bone marrow involvement by an isolated interstitial lymphoid aggregate exhibiting the pattern and phenotype described for follicular lymphoma in situ (FLIS) has not been reported before. The detection of clinically silent FL in this case highlights the necessity of complete staging workup when such lesions are encountered in biopsies.
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